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实验研究关于皮肤状甲状腺癌的新陈代谢机制的变化,并与哈希莫托的甲状腺炎复杂
Danyang Sun1,2, Yujie Zhang3,4, Dan Wang3
1Department of Nuclear Medicine, Tianjin Medical University General Hospital Airport Site, Tianjin, China.
Heliyon
|October 20, 2023
概括
在患有和没有哈希莫托甲状腺炎 (HT) 的患者之间发现了甲状腺 papillary carcinoma (PTC) 的代谢差异. 这些发现表明,特定的代谢途径可能会将HT和PTC发育联系起来,有助于诊断.
科学领域:
- 生物化学 生物化学
- 在瘤学瘤学.
- 代谢学 代谢学 代谢学
背景情况:
- 在患有哈希莫托甲状腺炎 (HT) 和没有HT的患者中,甲状腺 papillary carcinoma (PTC) 背后的代谢机制是有争议的.
- 了解这些差异对于探索HT和PTC之间的关系至关重要.
研究的目的:
- 在正常和HT背景下分析PTC的代谢相似性和差异.
- 调查HT和PTC之间的潜在联系.
主要方法:
- 超高性能液态染色学四极时飞行质谱学 (UPLC-Q-TOF/MS) 用于分析61名PTC患者的组织.
- 使用HMDB和MetaboAnalyst 5.0.0进行了代谢物识别和途径分析.
- 接收器操作特征 (ROC) 曲线分析了已识别的生物标志物的诊断准确性.
主要成果:
- 确定了七种差异性代谢物 (氨酸,谷氨酸,氨酸,氨酸,酸,乌拉,氨酸,氨酸).
- 使用这些生物标志物的逻辑回归模型显示PTC具有良好的区分能力 (HT组的AUC为0.867,NC组为0.973).
- HT组表现出不同的代谢途径,包括氨基酸-tRNA生物合成和甘氨酸,血清素和三氨酸代谢.
结论:
- 在正常背景和HT背景之间,PTC表现出显著的代谢相似性和差异.
- 观察到的PTC和HT之间的相关性可能涉及氨基酸-tRNA生物合成和氨酸/氨酸代谢.
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