产前皮质类固醇治疗和儿童的传染病:全国性的观察性研究
Katri Räikkönen1,2, Mika Gissler3,4,5, Eero Kajantie6,7,8,9
1Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
The Lancet regional health. Europe
|October 20, 2023
概括
在母亲的产前皮质类固醇治疗 (ACT) 与高期和晚期早产婴儿因传染病住院的增加有关. 然而,非常到中度的早产婴儿没有增加风险,这表明要仔细考虑ACT的益处和风险.
科学领域:
- 新生儿医学 新生儿医学
- 儿童传染病 儿童传染病
- 免疫学 免疫学 免疫学
背景情况:
- 产前皮质类固醇治疗 (ACT) 对早产婴儿的结果至关重要,但可能会影响免疫发育和疾病风险.
- 需要进一步调查ACT与在预产和早产婴儿中的传染病之间的关联.
研究的目的:
- 为了研究母亲ACT和传染病之间的关系,在产期,晚期早产和非常到中度早产的孩子中.
- 评估ACT对住院治疗日,病期和4岁以下感染性疾病的专科护理访问的影响.
主要方法:
- 芬兰进行的一项全国性队列研究 (2006-2021) 包括所有单独生育的活产.
- 母亲ACT是暴露;主要结局包括传染病诊断,住院日,病期和门诊.
- 定期出生的同胞兄弟姐妹的比较被用来控制未测量的家族因素.
主要成果:
- 接受ACT治疗的期满和晚期早产婴儿的住院治疗日数,发作和针对传染病的专科护理访问显著增加.
- 暴露于ACT的非常到中度早产婴儿表现出与未暴露的婴儿相似的结果,在3-4岁时住院日/情节较少.
- 按期出生的兄弟姐妹的分析证实了与ACT相关的传染病负担增加.
结论:
- 暴露于ACT与期满和晚期早产婴儿感染传染病的风险增加有关.
- 这些发现支持仔细考虑ACT的风险和益处,特别是关于潜在的长期免疫效应.
- 进一步的研究可能是有必要的,以了解这些观察到的关联背后的机制.
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