在用免疫检查点抑制剂治疗的瘤中使用周围免疫炎症血标记:INVIDIa-2研究子分析
Shobana Anpalakhan1, Alessio Signori2, Alessio Cortellini3,4
1Portsmouth Hospitals University NHS Trust, Portsmouth, UK.
iScience
|October 20, 2023
概括
中性粒细胞与淋巴细胞的比率 (NLR) 和全身免疫炎症指数 (SII) 预测了接受免疫检查点抑制剂 (ICI) 的非小细胞肺癌,细胞癌和黑色素瘤患者的整体存活率. 这些炎症标志物在癌症免疫治疗中是有价值的预后指标.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 生物标志物 生物标志物
背景情况:
- 中性细胞与淋巴细胞比率 (NLR) 和全身免疫炎症指数 (SII) 是各种癌症的新兴预后标志物.
- 它们在非小细胞肺癌 (NSCLC),细胞癌 (RCC) 和用免疫检查点抑制剂 (ICI) 治疗的黑色素瘤患者中的作用需要进一步调查.
研究的目的:
- 评估NLR和SII对ICI治疗的癌症患者整体存活 (OS) 的预后价值.
- 为了评估这些标记,使用文献报告 (LR),接收器运行特征曲线 (ROC) 衍生 (ROC) 截止值,并作为连续变量 (CV).
主要方法:
- 分析INVIDIa-2研究数据,包括接受ICI的NSCLC,RCC和黑色素瘤患者.
- 进行了多变量分析,以评估NLR和SII对OS的独立预测值.
- 使用LR,ROC衍生的切断值以及连续变量来分析NLR和SII值.
主要成果:
- 具有ROC截止值 (分别<3.4和<831) 的NLR和SII是OS的独立预测指标 (p <0.001).
- 在所有评估的癌症类型 (NSCLC,RCC,黑色素瘤) 中,SII显著预测了OS,无论使用的切断方法 (LR,ROC,CV).
- 在一线和二线或超越ICI治疗环境中,NLR和SII证明了OS的预后价值.
结论:
- 在接受ICI治疗的NSCLC,RCC和黑色素瘤患者中,NLR和SII是整体生存的显著预测因素.
- 这些易于获得的炎症标志物可以帮助接受免疫治疗的癌症患者的风险分层和治疗决策.
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