在FOXP2中基于PolyQ长度的发声频率的分子编码.
Serena Vaglietti1, Veronica Villeri1, Marco Dell'Oca1
1Rita Levi Montalcini Department of Neuroscience, University of Turin, 10125 Turin, Italy.
iScience
|October 20, 2023
概括
这是FOXP2蛋白质.
科学领域:
- 进化生物学是进化的生物学.
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 福克斯P2基因对发声和言语至关重要.
- 在哺乳动物中,FOXP2含有可变的多Q重复区域 (Q1和Q2).
- 对于FOXP2 polyQ长度变化的功能意义尚不清楚.
研究的目的:
- 为了研究FOXP2 polyQ长度变化和发音频率之间的关系.
- 探索这种关系背后的分子机制.
- 检查FOXP2和FOXP1.1中的融合进化的模式.
主要方法:
- 在哺乳动物物种中对FOXP2和FOXP1多Q长度的比较进化分析.
- 对FOXP2 polyQ通道结构,凝结物形成和液态液相分离 (LLPS) 的分子研究.
- 整合进化和分子数据,将多Q长度与发音频率联系起来.
主要成果:
- FOXP2 Q1/Q2 长度的比率与发声频率范围 (超声波到超声波) 有定量相关.
- 在具有相似发声频率的物种 (例如蝙蝠和超声波物种) 中观察到聚Q长度比的融合演变.
- FOXP2 polyQ通道形成分子凝聚物并驱动LLPS,其长度变化影响结构,LLPS和转录活动.
结论:
- 在FOXP2中的PolyQ长度变化作为发声频率的分子代码.
- 这提供了一个新的机制,通过蛋白质结构和LLPS将基因型与声学表型联系起来.
- 融合进化突出了FOXP2 polyQ长度调节在语音通信中的适应意义.
更多相关视频
08:16Author Spotlight: Exploring the Frontier of mRNA Research with Poly A Tail Analysis Techniques
Published on: January 12, 2024
995
08:22A Robust Polymerase Chain Reaction-based Assay for Quantifying Cytosine-guanine-guanine Trinucleotide Repeats in Fragile X Mental Retardation-1 Gene
Published on: September 16, 2019
7.9K
相关概念视频
01:11Genetic Lingo
102.9K
Overview
102.9K
02:24Ribosome Profiling
3.5K
Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
3.5K
02:02Cis-regulatory Sequences
3.0K
3.0K
01:44Complementary DNA
29.5K
Overview
29.5K
02:57Real Time RT-PCR
57.3K
Real-time reverse transcription-polymerase chain reaction, or Real-time RT-PCR, is an analytical tool used to determine the expression level of target genes. The method involves converting mRNA to complementary DNA with the help of an enzyme known as reverse transcriptase, followed by the PCR amplification of the cDNA. These two processes can be performed simultaneously in a single tube or separately as a two-step reaction.
The real-time quantification of the number of amplified products is...
The real-time quantification of the number of amplified products is...
57.3K
01:24Transposons
39
Transposons, or "jumping genes," are small mobile genetic elements (MGEs) that range from 700 to 40,000 base pairs in length. They are found in all organisms and can move within the same chromosome or transfer to different chromosomes. In some cases, transposons can also jump between different host DNA molecules, such as plasmids or viruses, contributing to genetic variability.Barbara McClintock first discovered these mobile genetic elements in the 1940s while studying maize genetics, and she...
39