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由妊娠第三季度等效乙醇暴露引起的神经行为变化通过叶酸的管理被抑制

Leonardo Marengo¹, Agostina Barey¹, Agustín Salguero¹

¹Instituto de Investigación Médica M. y M. Ferreyra, INIMEC-CONICET, Universidad Nacional de Córdoba, Córdoba, Argentina.

Developmental psychobiology

|October 20, 2023

概括

产前暴露于乙醇 (PEE) 可能会损害婴儿的神经发育. 在关键的产后期服用叶酸补充剂显著减轻了Wistar大鼠的一些有害的神经行为影响.

科学领域:

神经科学是一个神经科学.
发展生物学发展生物学
药理学药理学是指药理学的学科.

背景情况:

产前暴露于乙醇 (PEE) 会导致胎儿神经发育障碍.
动物的产后4-9天反映了人类第三个月的发育,这是突触生成和髓化的一个关键时期.
叶酸对DNA合成和新陈代谢至关重要,正在研究其对PEE的保护作用.

研究的目的:

在关键的动物出生后发育期内,对同时给予叶酸和乙醇的神经行为影响进行研究.
评估叶酸是否可以减轻PEE诱导的神经行为缺陷在雄性和雌性Wistar大鼠.

主要方法:

在出生后4-9天期间,Wistar老鼠幼同时接受乙醇 (5g/kg/天) 和叶酸 (20 mg/kg/天).
神经行为评估包括在PDs 16-18期间的光暗盒,开放场和同心方形场测试.
断奶后的测试评估了糖糖偏好和乙醇摄入量.

主要成果:

PEE降低了婴儿的体重,但没有显著改变乙醇自给药或开放场地/明暗盒的性能.
在同心方形现场试验中,PEE降低了糖偏好和增加了寻求庇护的行为.
叶酸的使用显著抑制了PEE诱导的糖糖摄入量减少和寻求庇护的增加.

结论:

叶酸补充剂可以改善产前乙醇暴露引起的特定神经行为缺陷.
叶酸显示出作为一种安全的治疗剂的潜力,可以减轻PEE的一些不良影响.
在关键的产后发育期间同时服用叶酸和乙醇,可以有望防止PEE诱导的神经行为变化.

关键词:

青春期大鼠的成长过程这是一个无情的世界,无情的世界.焦虑是一种焦虑.乙醇摄入量乙醇摄入量在产前暴露于乙醇.在化前的老鼠.

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