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活跃和被动循环降低帕金森病中体下β振荡

Vasiliki Bougou^1,2, Michaël Vanhoyland^1,2,3, Thomas Decramer^1,2,3

¹Research Group of Experimental Neurosurgery and Neuroanatomy, Department of Neurosciences, KU Leuven and the Leuven Brain Institute, Leuven, Belgium.

Movement disorders : official journal of the Movement Disorder Society

|October 20, 2023

概括

骑自行车,特别是被动骑自行车,在帕金森病患者中强烈抑制β振荡. 这种β抑制在那些步态结的人群中更为明显,这表明了节奏动员的治疗潜力.

科学领域:

神经科学是一个神经科学.
运动障碍运动障碍
生物医学工程生物医学工程

背景情况:

帕金森病 (PD) 影响运动控制,步态结 (FOG) 是一个使人虚弱的症状.
了解在PD中像骑自行车一样保存的运动能力对于开发有效疗法至关重要.
之前的研究表明,骑自行车可以通过抑制亚thalamic核 (STN) 的β振荡来增强运动持续性.

研究的目的:

研究主动和被动循环对PD患者STN神经活动的影响.
为了比较患有FOG和没有FOG的患者之间的这些影响.
确定骑自行车时感官输入在调节大脑活动中的作用.

主要方法:

从STN记录了12名PD患者的局部现场潜力 (LFPs) (6名有FOG,6名没有FOG).
贝塔 (13-30 Hz) 和高马 (60-100 Hz) 功率在各种节奏的积极和被动循环过程中被分析.
被动循环使用电机驱动的设置来隔离传感输入效应.

主要成果:

积极和被动循环都显著抑制了病理性β活性.
与被动自行车相比,积极自行车显示高马波段活动增加.
在FOG患者中,β抑制更为明显,特别是在被动循环期间.
节奏没有影响骑自行车对神经活动的观察到的影响.

结论:

循环期间的自身感受输入与PD中的β波抑制有关.
持续的外部感官输入和来自节奏循环的自身感知反有助于运动控制.
通过骑自行车进行系统的被动动化可以为PD患者提供治疗益处,特别是那些患有FOG的患者.

关键词:

电力生理学电力生理学运动障碍运动障碍亚体的细胞核.

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