叶酸 - 基托涂层奎思脂质体用于向癌症治疗
Chun-Hui Chang1, De-En Han1, Yu-Ying Ji1
1College of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou, 450046, P.R. China.
Current pharmaceutical biotechnology
|October 20, 2023
概括
这项研究开发了向素脂质体 (FA-CS-QUE-Lip),以克服素的作用.
科学领域:
- 纳米技术在药物输送中的应用
- 癌症治疗方法 癌症治疗方法
- 药理学 药理学是指药理学的学科.
背景情况:
- 奎尔丁显示出潜在的抗瘤作用,但由于向不良和固有的缺陷,其临床使用面临限制.
- 开发有针对性的输送系统对于提高奎尔塞丁对瘤的疗效至关重要.
研究的目的:
- 准备和描述积极向的叶酸 - 基托改性奎尔素脂质体 (FA-CS-QUE-Lip).
- 评估FA-CS-QUE-Lip的体外和体内抗瘤活性.
主要方法:
- 使用盒式模拟设计 (Box-Behnken Design) 制定的最佳素脂质体 (QUE-LP).
- FA-CS-QUE-LP是通过将叶酸基多复合物 (FA-CS) 与QUE-LP结合而制成的.
- 在试验室释放,细胞毒性 (MTT对HepG2细胞的测定),以及在小鼠体内的药理动力学/药理动力学研究.
主要成果:
- FA-CS-QUE-LP显示了最佳特征:261.6纳米大小,22.3毫伏泽塔电位,98.63%的封装效率和持续释放.
- 与瑞溶液相比,FA-CS-QUE-LP显示了对HepG2细胞的明显更高的抑制率.
- 在体内研究显示,S180瘤携带小鼠的素的药理动力学和显著的瘤生长抑制 (30.26%重量,37.35%体积) 发生了改变.
结论:
- FA-CS-QUE-LP有效地抑制HepG2细胞,并在体内表现出抗瘤活性.
- 这种向的脂质体配方改善了奎尔塞丁的药动力学特征,并为癌症治疗提供了一个有前途的策略.
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