血友病老年人的关节状况,疼痛和生活质量:一个病例对照研究
Valérie-Anne Chantrain1,2,3,4, Anthe Foubert1,2,3, Mira Meeus1,2
1Faculty of Medicines and Health Sciences, Research Group (MOVANT), Department of Rehabilitation Sciences and Physiotherapy (REVAKI), University of Antwerp, Wilrijk, Belgium.
概括
患有中度/严重血友病的老年人经历了严重的关节问题,疼痛和生活质量下降. 一些轻度血友病患者也表现出症状,但与健康对照人群没有显著差异.
科学领域:
- 老年学是指老年学的学科.
- 血液学 血液学 血液学
- 类风湿病学 类风湿病学
背景情况:
- 患有血友病 (PwH) 的老年人经常患有血友病关节病,疼痛和与健康相关的生活质量 (HR-QoL) 的降低.
- 患有轻度血友病的老年人的健康状况尚未得到充分研究.
- 这项研究通过比较轻度,中度/重度血友病的老年人和健康对照者的关节状况,疼痛和HR-QoL来解决这一差距.
研究的目的:
- 为了比较轻度血友病,中度/重度血友病和健康对照的老年人之间的关节状况,疼痛水平和与健康有关的生活质量 (HR-QoL).
- 评估血友病严重程度对老年人关节健康和功能结果的影响.
- 提供有关老年人面临的具体挑战的见解.
主要方法:
- 一项涉及老年人 (≥60岁) 患有血友病A/B (轻度,中度/重度) 和年龄相匹配的健康对照 (HCs) 的病例控制研究.
- 通过超声波 (HEAD-US) 和体检 (HJHS 2.1) 评估关节状态.
- 使用简要疼痛清单和压力疼痛值 (PPT) 评估疼痛. 通过2分钟步行测试,定时启动和启动以及HAL测量的功能限制. 使用EQ-5D-5L进行HR-QoL评估.
主要成果:
- 与轻度PwH和HC相比,中度/重度PwH的关节状况明显恶化,PPT较低,HR-QoL较差 (p ≤0.010).
- 在中度/重度PwH中,HEAD-US显示100%的膝盖和94%的脚异常,而在轻度PwH中,异常分别为50%和61%.
- 虽然80%的中度/重度PwH报告疼痛,但57%的轻度PwH确实有. 一些轻微的PwH表现出关节异常,疼痛和功能限制,但与HCs没有显著差异.
结论:
- 患有中度/严重血友病的老年人表现出明显的关节/功能障碍,疼痛和HR-QoL降低.
- 一部分轻度血友病的老年人可能会出现关节异常,疼痛和功能限制,尽管在统计学上与健康对照人群没有差异.
- 这些发现强调了老年人中中度/重度血友病的重大负担,并强调需要对轻度病例进行进一步调查.
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