使用化酶5抑制剂与眼部不良事件无关
Federico Belladelli1,2,3, Shufeng Li3, Chiyuan A Zhang3
1Division of Experimental Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan 20132, Italy.
The journal of sexual medicine
|October 20, 2023
概括
用代酶5抑制剂 (PDE5i) 治疗勃起功能障碍或良性前列腺激增并没有增加眼部事件的风险. 这项研究发现PDE5i使用与血清性视网膜脱落,视网膜血管封闭或缺血性视神经病变之间没有一致的关联.
科学领域:
- 眼科医生 眼科 眼科
- 药理学 药理学是指药理学的学科.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 固酶5抑制剂 (PDE5is) 用于治疗勃起功能障碍 (ED) 和良性前列腺增生 (BPH).
- 以前的报道表明可能的眼部副作用,包括血清性视网膜脱落 (SRD),视网膜血管封闭 (RVO) 和缺血性视神经病变 (ION).
研究的目的:
- 调查PDE5i使用与眼部事件 (SRD,RVO,ION) 的风险之间的关联.
- 为了比较ED和BPH指示的PDE5i用户和非用户之间的眼部事件风险.
主要方法:
- 利用IBM MarketScan数据库 (2007-2021) 对ED和BPH诊断的患者进行了分析.
- 采用考克斯的比例危险模型来计算眼部事件的危险比率 (HRs),调整多个共变量.
- 分析了与PDE5i治疗与其他ED/BPH治疗相关的风险.
主要成果:
- 在ED患者中,PDE5i的使用与SRD,RVO或ION无关.
- 在BPH患者中,PDE5i使用与RVO风险增加有关 (HR,1.14).
- 其他BPH治疗 (5-α减少酶/α抑制剂,手术) 也显示RVO风险增加.
结论:
- 对ED或BPH的PDE5i使用似乎不会增加眼部不良事件的风险.
- 在PDE5i使用和SRD,RVO或ION之间没有观察到一致的关联.
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