心率变化是否可以作为肺高血压患者的预后因素? 一个单中心试点研究
Ogtay Musayev1, Meral Kayıkçıoğlu2, Shafa Shahbazova1
1Department of Cardiology, Central Clinic Hospital, Baku, Azerbaijan.
概括
心率变化 (HRV) 在肺高血压 (PH) 患者中降低,并预测不良事件. 这种非侵入性的霍尔特电图测量有助于短期PH预后的风险分层.
科学领域:
- 心脏病学 心脏病学
- 自主神经系统功能 自主神经系统功能
背景情况:
- 心率变化 (HRV) 量化了心脏自主心律.
- 肺高血压 (PH) 显著影响心血管健康和预后.
研究的目的:
- 研究PH患者HRV与短期预后之间的关联.
- 评估HRV作为PH中不良事件的潜在预测因素.
主要方法:
- 64名PH患者和69名对照人接受了24小时的霍尔特心电图,心声和实验室测试.
- 分析了HRV指数 (取决于时间和频率).
- 在6个月的随访期间,对不良事件 (右心衰竭,住院,昏迷,死亡) 进行了跟踪.
主要成果:
- 与对照组相比,PH患者的时间和频率依赖HRV指数显著降低.
- 较低的HRV指数与较差的功能类和不良事件风险增加相关.
- 死亡率与减少的HRV参数显著相关,包括SDNN和SDANN.
结论:
- 在PH患者中,HRV显著降低,与临床状态相关.
- HRV指数显示出预测PH患者临床恶化,不良事件和死亡率的潜力.
- 通过Holter-ECG进行非侵入性HRV评估是PH中短期风险分层的实用工具.
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