基于的生物材料在骨组织工程中的发展:一篇综述
Jiaxin Wu1, Xinting Cheng1, Jicenyuan Wu1
1State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
概括
基于的生物材料由于其强度和安全性,显示出对骨再生的希望. 目前正在制定策略,以控制它们的降解速度,以获得更好的骨修复结果.
科学领域:
- 生物材料科学 生物材料科学
- 整形外科手术 整形外科手术
- 再生医学是一种再生医学.
背景情况:
- 骨再生对于治疗复杂的骨缺陷至关重要.
- 当前的工程材料往往缺乏理想的机械,骨质生成和生物相容性质.
- 基于的生物材料由于机械强度和生物安全性而具有潜力.
研究的目的:
- 审查基生物材料的骨质生成机制和降解率要求.
- 要突出最近在生物医学应用的骨再生的进步.
- 为了鼓励在骨修复中的进一步临床使用.
主要方法:
- 关于用于骨组织工程的基于的生物材料的文献综述.
- 对合金,表面改造和复合材料合成进行分析,以提高性能.
- 检查骨质生成机制和降解控制策略.
主要成果:
- 基于的生物材料具有出色的机械强度和生物安全性.
- 快速降解是关键的限制,导致过度的Mg2+和的生产.
- 合金,涂料和复合材料在控制降解速度方面是有效的.
结论:
- 优化降解速率对于成功利用基于Mg的材料进行骨再生至关重要.
- 对基于Mg的生物材料的进一步研究可以带来增强的临床应用.
- 基于Mg的生物材料代表了解决关键骨缺陷挑战的有希望的途径.
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