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Updated: Jul 12, 2025

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens
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在高度可变的生殖线编码区域之间保持的生物物理兼容性塑造了TCR-MHC相互作用

Christopher T Boughter1, Martin Meier-Schellersheim1

  • 1Computational Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, United States.

eLife
|October 20, 2023
PubMed
概括

与-MHC复合体的T细胞受体 (TCR) 相互作用对于适应性免疫至关重要. 这项研究全面分析了生殖系编码的接触,揭示了生物物理兼容性,而不是序列保存,可能决定了结合性方向.

关键词:
在MHC中,MHC是最重要的.在TCR中,可以使用TCR.生物信息学是一种生物信息学.生物物理学的生物物理学.共同进化的共同进化生殖线相互作用的生殖线相互作用人类 人类 人类 人类 人类 人类 人类免疫学 免疫学 免疫学这是一种炎症炎症炎症炎症.分子生物物理学分子生物物理学结构生物学结构生物学

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