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两个人类大脑系统在微观结构上与肥胖有关
Manfred G Kitzbichler1, Daniel Martins2, Richard A I Bethlehem1
1Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom.
eLife
|October 20, 2023
概括
肥胖与明显的脑部变化有关:前额叶区域增加水分,中间部区域减少神经元密度. 这些发现表明大脑结构和肥胖之间存在双向关系,受遗传学和免疫功能的影响.
科学领域:
- 神经成像是一种神经成像.
- 肥胖问题研究研究
- 遗传学 是一个遗传学.
背景情况:
- 肥胖和人类大脑结构之间的复杂关系仍然不太清楚.
- 微结构性MRI指标为大脑组织组成提供了洞察力.
研究的目的:
- 调查肥胖 (腰比) 和大脑微结构指标 (同位体体积分数和细胞内体积分数) 之间的关联.
- 探索这些与肥胖相关的大脑变化的遗传基础和炎症相关性.
主要方法:
- 利用了来自约3万名英国生物库参与者的扩散权重MRI数据.
- 分析了腰与部比率和同位体体积分数 (自由水) 和细胞内体积分数 (神经元密度) 之间的关联.
- 检查了与C反应蛋白 (CRP) 地图的遗传相关性和关系.
主要成果:
- 确定了与肥胖相关的两个不同的大脑系统:对同位体体积分数的前额//系统和对细胞内体积分数的中间时//系统.
- 在这些系统中观察到不同的基因表达模式和受体密度.
- 在腰与部比率和细胞内体积分数之间发现了显著的遗传相关性,但不是同位素体积分数.
结论:
- 肥胖与特定神经系统中大脑水含量和神经元密度的明显变化有关.
- 研究结果支持一种双向模型,其中大脑结构可能会影响肥胖风险 (神经炎密度),肥胖可能会影响大脑结构 (通过免疫激活的水含量).
- 这表明先天性免疫路径在调解肥胖对大脑水含量影响方面可能发挥作用.
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