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perfluorooctane 硫酸盐及其替代品 6:2 化多化以太硫酸盐对地的比较毒理作用

Yanhui Ge¹, Zhan Wang¹, Xuelu Chen¹

¹School of Environmental Science and Safety Engineering, Tianjin University of Technology, Tianjin, China.

Environmental toxicology and chemistry

|October 20, 2023

概括

6:2 化多乙烯硫酸盐 (F-53B) 对比 perfluorooctane 硫酸盐 (PFOS) 更有毒. F-53B会导致更大的氧化应激和组织损伤,这表明土壤环境中的生态风险更高.

科学领域:

环境毒理学环境毒理学
生态毒理学生态毒理学
土壤科学土壤科学

背景情况:

6:2化多化乙烯硫酸盐 (F-53B) 是生态系统中发现的一种PFOS替代品.
它对土壤生物,特别是虫的毒性尚不清楚.
了解F-53B的影响是非常重要的,因为它越来越多地存在于环境中.

研究的目的:

为了比较研究F-53B和PFOS在土虫Eisenia fetida中的毒性.
评估这些化学物质对氧化应激,代谢过程和细胞完整性的影响.
提供关于F-53B对土壤生态系统的生态风险的见解.

主要方法:

使用中位数致命度 (LC50) 确定的急性毒性测试.
生物化学试验用于测量氧化应激标志物 (SOD,POD,CAT,MDA).
转录组和代谢组分析,以评估对代谢途径和细胞功能的影响.

主要成果:

F-53B对虫的急性毒性明显高于PFOS.
无论是F-53B还是PFOS都诱导了氧化应激,而F-53B的效果更为明显.
转录组和代谢组数据显示,与PFOS相比,F-53B更强烈地诱导了亡,铁亡和细胞外基质破坏.

结论:

对于虫来说,F-53B的毒理风险比PFOS更大.
F-53B对生理学产生重大影响,包括氧化应激和细胞完整性.
这些发现突出了F-53B对土壤生物和生态系统的潜在生态毒理威胁.

关键词:

6:2 化多化乙太硫酸盐抗氧化反应的抗氧化反应代谢学代谢学代谢学 perfluorooctane 硫酸盐的使用情况文字转录学 (Transcriptomics) 是一个学科.

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