不同高血压现象的自主调节 - - HELIUS研究
D Collard1, E M C Vriend1,2, H Galenkamp2
1Amsterdam UMC, University of Amsterdam, Department of Internal Medicine, Section Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands.
Blood pressure
|October 20, 2023
概括
在年轻人中,孤立的缩性高血压 (ISH) 显示出正常的交感活动. 然而,其他高血压类型 (IDH,SDH) 和老年人中的所有高血压都表明交感控制增加,这表明高血压表型中的自主功能障碍.
科学领域:
- 心脏病学 心脏病学
- 自主神经系统研究 自主神经系统研究
- 高血压的表型化 高血压的表型化
背景情况:
- 高血压表型 (ISH,IDH,SDH) 具有不同的预后和与同情活动的潜在联系.
- 心脏自主功能评估可能会揭示与高血压类型的差异性关联.
研究的目的:
- 研究心脏自主功能与不同高血压表型之间的关系.
- 为了确定同情活动是否在隔离的静缩,静缩和联合高血压之间有所不同.
主要方法:
- 利用了10,221名多民族HELIUS研究参与者 (18-70岁) 的连续手指血压 (BP) 记录.
- 评估的交叉相关性巴罗反射灵敏度 (xBRS) 和心率变化 (HRV) 作为自主功能的测量.
- 将高血压分为ISH,IDH和SDH,使用回归分析分析年龄和性别分层的差异.
主要成果:
- 在年轻的成年人中,孤立的缩性高血压 (ISH) 与正常高血压相比,xBRS没有显著差异.
- 在年轻人中,孤立的透气性高血压 (IDH) 和结合的系统-透气性高血压 (SDH),在老年人中,所有表型都表现出明显较低的xBRS.
- 心率变化 (HRV) 模式反映了男性的xBRS,但不是女性.
结论:
- 年轻人中的ISH与增加的同情力驱动无关,与IDH和SDH不同.
- 增加的同情控制与年轻参与者的IDH和SDH以及老年人的所有高血压表型有关.
- 自主性失调可能解释高血压表型中观察到的预后差异.
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