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Updated: Jul 12, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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在 silico 计算药物发现:开发新型 JAK3 抑制剂的蒙特卡洛方法

Abdelmoujoud Faris1, Ivana Cacciatore2, Ibrahim M Ibrahim3

  • 1LIMAS, Department of Chemical Sciences, Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University, Fez, Morocco.

Journal of biomolecular structure & dynamics
|October 20, 2023
PubMed
概括

研究人员设计了针对自身免疫性疾病的新型共价Janus激酶3 (JAK3) 抑制剂. 计算机建模识别出有前途的候选药物,对癌症和类风湿关节炎等疾病有潜在的治疗应用.

关键词:
抑制了JAK3的发生.蒙特卡罗的蒙特卡罗是一个非常好的城市.癌症 癌症 癌症 癌症 癌症药物设计 药物设计类风湿性关节炎 类风湿性关节炎小分子抑制剂 小分子抑制剂治疗目标是治疗的目标.

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