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对纤维化强效和选择性MMP-7抑制剂的结构优化和生物评估

Kumi Abe-Sato1, Hideaki Tabuse1, Harumi Kanazawa1

  • 1Medicinal Chemistry Laboratories, Taisho Pharmaceutical Co., Ltd., 1-403, Yoshino-Cho, Kita-Ku, Saitama, Saitama 331-9530, Japan.

Journal of medicinal chemistry
|October 20, 2023
PubMed
概括

选择性矩阵金属蛋白酶-7 (MMP-7) 抑制剂是使用分子杂交开发的. 化合物15在体内表现出强烈的抑制作用,并预防纤维化进展.

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Role of Matrix Metalloproteases in Degradation of ECM01:23

Role of Matrix Metalloproteases in Degradation of ECM

Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult body.
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