基于SEER数据库开发和验证,针对患有清细胞细胞癌的老年患者进行预后性诺图
Mingxin Lin1, Cong Wang, Jianan Zhou
1The First Affiliated Hospital of Dalian Medical University, Dalian City, China.
Medicine
|October 20, 2023
概括
新的诺姆图模型预测了老年清细胞细胞癌 (ECCRCC) 患者的存活率. 这些模型改进了当前的分期系统,有助于治疗决策,以获得更好的患者结果.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 生物统计学 生物统计学
背景情况:
- 清细胞细胞癌 (ccRCC) 是癌最常见的亚型.
- 准确的预后模型对于指导ccRCC的老年患者的治疗决策至关重要.
- 现有的分期系统可能无法充分捕捉这一人口中生存预测的复杂性.
研究的目的:
- 开发和验证用于预测患有清细胞细胞癌 (ECCRCC) 的老年患者整体存活率 (OS) 的诺莫格拉姆模型.
- 与AJCC分阶段系统相比,评估开发的诺姆图的预测性能.
主要方法:
- 利用监测,流行病学和最终结果 (SEER) 数据库从2010年至2015年的患者数据.
- 随机地将数据分为培训 (70%) 和验证 (30%) 队列.
- 使用校准曲线,ROC曲线,决策曲线分析和C指数进行模型评估.
主要成果:
- 包括9201名符合条件的ccRCC的老年患者.
- 实现了高预测准确度,C指数为0.710 (培训) 和0.709 (验证).
- 在AJCC阶段,诺莫图表表显示出优异的预测性能,预测和观察生存时间之间有密切一致.
结论:
- 开发的诺莫格拉姆模型为预测老年ccRCC患者的OS提供了强大的工具.
- 这些名图可以作为临床决策和治疗规划的宝贵辅助.
- 这项研究突出了名录的潜力,以提高ECCRCC的预后准确性.
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