糖尿病和静脉血栓塞栓症之间的关联:系统性审查和元分析
Chaowei Ding1,2, Chang Guo2, Dan Du2
1Department of Respiratory and Critical Care Medicine, Xiamen Humanity Hospital Fujian Medical University, Xiamen, Fujian, China.
Medicine
|October 20, 2023
概括
糖尿病 (DM) 不显著增加静脉血栓塞栓症 (VTE) 的风险,身体质量指数作为一个关键的混因素. 然而,患有VTE的DM患者面临更高的死亡风险.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 糖尿病 (DM) 是心血管疾病的一个已知的危险因素.
- 由于研究结果相互矛盾,DM与静脉血栓栓塞 (VTE) 之间的关联尚未得到充分确立.
研究的目的:
- 进行一项元分析,评估DM在VTE形成和预后中的作用.
- 为了澄清DM和VTE风险和结果之间的关系.
主要方法:
- 在PubMed和EMBASE数据库中进行了全面的搜索,截至2022年9月15日.
- 包括50个队列和病例控制研究,使用纽卡斯尔-太华尺度评估质量.
- 聚合几率比率 (ORs) 和95%置信区间 (CI) 使用固定或随机效应模型进行计算.
主要成果:
- 当调整为体重指数 (OR1.04,95% CI:0.94-1.15) 时,DM与VTE风险没有显著关联.
- 患有VTE的DM患者表现出短期 (OR 1.20,95% CI: 1.19-1.21) 和长期死亡 (OR 1.58,95% CI: 1.26-1.99) 的风险增加.
结论:
- 身体质量指数是DM和VTE风险之间的关系的一个重要混因素.
- 虽然DM可能不会直接增加VTE风险,但它与VTE患者的预后较差和死亡率增加有关.
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