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疫苗对B.1.617.2在重症监护病房中的有效性
Ibrahim Koc1, Sevda Unalli Ozmen2, Olgun Deniz3
1Bursa City Hospital Pulmonary Medicine, Bursa, Turkey.
生物科技和西诺瓦克的疫苗显著减少了感染B.1.617.2变种的患者的严重疾病,输管和死亡率. 接种疫苗,特别是两剂BioNTech或三剂Sinovac,改善了生存率.
科学领域:
- 传染性疾病 传染性疾病
- 疫苗学 疫苗学 疫苗学
- 关键护理医学 关键护理医学
背景情况:
- SARS-CoV-2的B.1.617.2 (三角洲) 变种对全球健康构成重大威胁.
- 现有疫苗的有效性,特别是BioNTech和Sinovac,针对来自Delta变种的严重结果仍然是一个关键的研究问题,特别是在重症患者中.
研究的目的:
- 评估BioNTech和Sinovac疫苗在预防感染SARS-CoV-2 B.1.617.2变种的患者中严重疾病,输管和死亡率方面的有效性.
- 为了比较接种疫苗和未接种疫苗的患者进入重症监护室的结果.
主要方法:
- 对208名未接种疫苗和234名接种疫苗的B.1.617.2变种感染患者进行了回顾性审查.
- 收集的数据包括疾病严重程度,临床症状,入院时的血氧和,以及重症监护室 (ICU) 住院期间的临床过程.
主要成果:
- 与未接种疫苗的人相比,接种疫苗的人死亡率,严重疾病和输管率较低.
- 接种疫苗组的生存率 (58.5%) 与未接种疫苗组 (35.1%) 相比较高.
- 具体的疫苗接种方案显示出不同的保护作用:2剂BioNTech和3剂Sinovac显示出显著的死亡率降低,而2剂Sinovac加1剂BioNTech似乎是最具保护性的.
结论:
- 在感染SARS-CoV-2 B.1.617.2变种的患者中,BioNTech和Sinovac的疫苗有效地减少了严重的结果,包括死亡率.
- 该研究强调了疫苗接种计划的重要性,其中某些组合在ICU环境中提供了针对严重COVID-19的增强保护.
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