周围血液α1-MG,DNMT1表达和糖尿病病病理性损伤的严重程度之间的相关性
Liang Jin1, Chao Niu, Yulong Ni
1Department of Hand and Foot Surgery, Xingtai People's Hospital, Xingtai, Hebei, People's Republic of China.
Medicine
|October 20, 2023
概括
周围血液中的α1-微球蛋白 (α1-MG) 和单细胞DNA甲基转移酶1 (DNMT1) 水平,以及血管内皮生长因子 (VEGF),在糖尿病病 (DN) 患者中升高. 这些标志物与病理损伤严重程度正相关.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
- 分子生物学分子生物学
背景情况:
- 糖尿病病 (DN) 是糖尿病的主要并发症,其特征是逐渐的损伤.
- 早期发现和评估DN严重程度对于有效管理至关重要.
- 需要在DN中反映病理的生物标志物.
研究的目的:
- 调查周围血液α1-微型血球蛋白 (α1-MG) 与单细胞DNA甲基转移酶1 (DNMT1) 表达之间的相关性,以及DN患者病理损伤的严重程度.
- 评估DN中α1-MG,DNMT1和血管内皮生长因子 (VEGF) 的诊断价值.
主要方法:
- 对比α1-MG和DNMT1表达,以及100名DN患者的VEGF水平与50名对照.
- 使用的接收器操作特征 (ROC) 曲线来评估诊断价值.
- 分析了生物标志物水平和病学评分 (IFTA,间歇性炎症,质分级) 之间的相关性.
主要成果:
- 与对照组相比,DN患者的α1-MG,DNMT1和VEGF水平显著更高 (P < .05).
- 在ROC曲线分析中,DN的诊断准确度很高 (AUC:α1-MG 0.907,DNMT1 0.923,VEGF 0.936).
- 生物标志物水平与IFTA评分,间歇性炎症和质分级 (r值从0.609到0.771,P<0.05) 有正相关.
结论:
- 周围血液α1-MG,单细胞DNMT1表达和VEGF水平的升高是DN的特征.
- 这些标记物对DN具有显著的诊断价值.
- 它们的水平与病理损伤的严重程度相关,这表明它们在评估DN进展中的有用性.
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