在患有冠状动脉疾病的印度人中,高密度脂蛋白异质性和功能
Himani Thakkar1, Vinnyfred Vincent1, Ambuj Roy2
1Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.
The Indian journal of medical research
|October 20, 2023
概括
高密度脂蛋白 (HDL) 抗氧化活性 (AOA) 的受损以及细分分布的改变与心血管疾病有关. 这些HDL变化可以区分急性和稳定的冠状动脉疾病患者.
科学领域:
- 心血管医学 心血管医学
- 脂质代谢 脂质代谢是什么
- 生物化学 生物化学
背景情况:
- 高密度脂蛋白 (HDL) 功能受损是心血管疾病的已知危险因素.
- 高密度胆固醇在逆胆固醇运输中起着至关重要的作用,并具有动脉动脉保护性.
研究的目的:
- 研究急性冠状动脉综合征 (ACS) 和稳定冠状动脉疾病 (SCAD) 患者的高密度胆固醇功能的变化,特别是抗氧化活性 (AOA) 和高密度胆固醇亚分数分布.
- 为了评估HDL参数在区分ACS和SCAD个体之间的准确性.
主要方法:
- 在200名CAD患者 (ACS和SCAD) 和60名对照人群中,使用沉方法分析了HDL亚分数分布.
- 使用无细胞光试验,以及对氧化酶 (PON1) 酶活性测量,评估了HDL抗氧化活性 (AOA).
主要成果:
- 较高的HDL抗氧化活性 (AOA) 和偏氧酶 (PON1) 活性与患冠状动脉疾病 (CAD) 的可能性较低有关.
- 在对照组和ACS患者中,AOA与HDL2-C/HDL3-C比率相关.
- 对AOA和HDL亚分数分布的综合分析在区分ACS和SCAD组时取得了72.8%的准确性.
结论:
- 降低高密度胆固醇的抗氧化活性 (AOA) 和改变高密度胆固醇的亚分数分布可能导致抗质保护作用降低.
- 这些高密度胆固醇 (HDL) 变化作为不同冠状动脉疾病患者群体之间的歧视.
相关概念视频
Coronary Artery Disease IV: Preventive Measures
23
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
23
Blood Studies for Cardiovascular System III: Serum Lipid Profile
168
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
168
Cholesterol: Significance and Regulation
560
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
560
Coronary Artery Disease II: Pathophysiology
12
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
12
Coronary Artery Disease I: Introduction
17
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
17
Atherosclerosis I: Introduction
9
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
9


