在肯尼亚和乌干达农村的门诊部门进行动态选择的艾滋病毒预防干预
Catherine A Koss1, James Ayieko2, Jane Kabami3
1University of California San Francisco, San Francisco California, USA.
AIDS (London, England)
|October 20, 2023
概括
动态选择性艾滋病毒预防 (DCP) 显著增加了门诊机构的生物医学预防覆盖范围. 与标准护理相比,这种以患者为中心的方法使个人使用暴露前预防 (PrEP) 或暴露后预防 (PEP) 的时间翻了一番.
科学领域:
- 公共卫生 公共卫生
- 传染病流行病学 传染病流行病学
- 临床试验 临床试验
背景情况:
- 撒哈拉以南非洲地区的门诊部门是诊断新的艾滋病毒感染的关键点.
- 在这些环境中,生物医学艾滋病毒预防策略的研究不足.
- 提供选择的服务交付模式可以改善预防覆盖范围.
研究的目的:
- 评估肯尼亚农村和乌干达门诊部门的动态选择艾滋病毒预防 (DCP) 干预措施.
- 在生物医学预防产品覆盖方面,将DCP与标准护理 (SOC) 进行比较.
主要方法:
- 一个个别随机试验比较DCP与SOC.
- DCP包括产品选择 (口服暴露前预防 [PrEP]或暴露后预防 [PEP]),艾滋病毒检测选项以及服务位置的灵活性.
- 主要结局是48周内PrEP/PEP覆盖的随访时间的比例.
主要成果:
- DCP干预导致PrEP/PEP覆盖了47.5%的随访时间,而SOC手臂的这一比例为18.3% (29.2%的差异).
- 参与DCP手臂的参与者显示,他们更多地接受了艾滋病毒自我检测和机构外访问.
- 干预的好处在不同性别之间是一致的,并且在自我报告的艾滋病毒风险期间更明显.
结论:
- 动态选择的艾滋病毒预防干预显著增加了一般门诊病房的生物医学预防覆盖率.
- 与标准护理相比,DCP模型表明,生物医学预防产品所覆盖的时间是标准护理的两倍.
- 提供选择的以患者为中心的方法有效地提高了资源有限的环境中的艾滋病毒预防.
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