RFC3作为一种新的预后生物标志物和头部和部状细胞癌的标
Keerthana Reddy Avs1, Chandra Pandi2, Balachander Kannan2
1Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, India.
Clinical oral investigations
|October 20, 2023
概括
复制因子C子单元3 (RFC3) 在头部和部状细胞癌 (HNSCC) 中被上调. 高RFC3表达表明预后不佳,并可能成为HNSCC患者的治疗点.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 癌症基因组学 癌症基因组学
背景情况:
- 头部和部状细胞癌 (HNSCC) 是一种常见的癌症.
- 在HNSCC中复制因子C子单元3 (RFC3) 的作用尚不清楚.
研究的目的:
- 调查RFC3在HNSCC进展中的重要性.
- 评估RFC3作为HNSCC的潜在预后生物标志物.
主要方法:
- 使用癌症基因组图谱 (TCGA-HNSCC) 数据集进行表达分析.
- 在口腔状细胞癌 (OSCC) 中使用RT-qPCR确认RFC3mRNA水平.
- 使用生物信息学工具评估生存率,免疫细胞相互作用和蛋白质网络.
主要成果:
- 在HNSCC和OSCC中,RFC3表达显著增加.
- 升级的RFC3与晚期瘤阶段,等级,转移和患者存活率降低相关.
- RFC3涉及到DNA复制,DNA修复,细胞循环和致癌途径 (MYC/MYCN,HIPPO,mTOR) 的研究.
- RFC3表达与免疫细胞透有关.
结论:
- RFC3作为HNSCC的新预后生物标志物.
- RFC3的功能机制要求对HNSCC的治疗向进行进一步的研究.
- 这项研究强调了RFC3作为HNSCC的预后指标的临床相关性.
更多相关视频
07:29Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
11.5K
11:28Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
Published on: May 11, 2016
8.6K
相关概念视频
Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
Rous Sarcoma Virus (RSV) and Cancer
5.1K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
5.1K
