时间对自杀死亡的影响:经验证据和可能的分子相关性
R Bhagar1, H Le-Niculescu1, K Roseberry1
1Department of Psychiatry, Indiana University School of Medicine, Neuroscience Research Building 200B, 320 W. 15thStreet, Indianapolis, IN, 46202, USA.
Discover mental health
|October 20, 2023
概括
自杀率在满月期间显著增加,特别是在老年人中. 这种时间效应可能与昼夜钟基因和环境光照暴露有关,这表明了预防自杀的新治疗点.
科学领域:
- 时间生物学 时间生物学
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
背景情况:
- 大众信仰和医学传说表明,满月和精神疾病恶化之间存在联系.
- 需要经验证据来验证在满月期间自杀率增加的假设.
研究的目的:
- 用实证分析,在满月期间是否增加了自杀.
- 识别与自杀相关的时间模式 (一天的时间,月份) 和潜在的分子机制.
主要方法:
- 从马里昂县验尸官办公室 (n=776) 分析了COVID前的自杀数据.
- 对血液生物标志物 (n=45) 进行自杀倾向的检查,重点关注昼夜钟基因.
- 统计分析以确定时间效应和生物标志物关联的显著性 (p值).
主要成果:
- 在满月周期间,自杀死亡人数显著增加 (p=0.037),特别是在55岁及以上的人群中 (p=0.019).
- 自杀死亡的高峰时间是在下午3-4点之间 (p=0.035) 和9月 (p=0.09).
- 富含昼夜钟基因的生物标志物 (例如,AHCYL2,GSK3B) 在这些高峰期预测自杀,并受到情绪稳定剂,抑郁症和酒精的影响.
结论:
- 存在对自杀倾向的时间影响,可能由生物钟介导并受到环境光线的影响.
- 昼夜时钟基因表达可能在观察到的自杀时间模式中起作用.
- 针对环境光暴露,并将其与药物和成治疗相结合,可以为预防自杀提供新的途径.
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