年轻的成年人身体活动轨迹和中年非酒精性脂肪性肝病
Junia N de Brito1, Daniel J McDonough2, Mahesh Mathew2
1Department of Family Medicine and Community Health, University of Minnesota Medical School, Minneapolis.
从年轻到中年保持强烈的体力活动 (VPA) 与非酒精性脂肪肝疾病 (NAFLD) 的风险较低有关. 这凸显了VPA对长期肝脏健康的重要性.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 运动科学 运动科学
背景情况:
- 非酒精性脂肪肝 (NAFLD) 是一个越来越令人担忧的疾病,为其预防和治疗,建议进行体力活动 (PA).
- 然而,不同强度的体力活动,特别是中度强度PA (MPA) 和强度强度PA (VPA) 对中年NAFLD患病率的长期影响尚不清楚.
研究的目的:
- 从年轻到中年,确定基于强度的体力活动的不同轨迹.
- 检查这些身体活动轨迹与中年非酒精性脂肪性肝病的患病率之间的关联.
主要方法:
- 一项以人口为基础的队列研究,涉及冠状动脉风险发展在年轻成年人 (CARDIA) 研究的2833名参与者.
- 身体活动 (MPA和VPA) 在25年内自报,非酒精性脂肪肝疾病在最后一年使用计算机断层扫描进行评估.
- 潜伏轨迹分析被用来识别不同的体力活动模式,并使用回归模型来评估与NAFLD的关联,调整共变量.
主要成果:
- 确定了三种中等强度体力活动 (MPA) 轨迹:非常低的稳定,低的增加和中等的增加.
- 确定了三个强烈强度体力活动 (VPA) 轨迹:低稳定,中度下降和高下降.
- 在中度下降和高下降VPA轨迹的参与者中,与低稳定VPA轨迹的参与者相比,在中年时,NAFLD的风险明显较低. MPA轨迹没有显示与NAFLD风险的显著关联.
结论:
- 在整个年轻和中年期保持更高水平的强烈强度体力活动与中年期非酒精性脂肪肝疾病的风险降低有关.
- 这些发现强调了促进持续的VPA在NAFLD预防的生命过程中的重要性.
- 公共卫生倡议应专注于开发可访问和公平的计划,鼓励终身VPA以减轻NAFLD风险.
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