磁共振对比媒体的新时代
Val M Runge1, Johannes T Heverhagen
1From the Department of Diagnostic, Interventional, and Pediatric Radiology, University Hospital of Bern, Inselspital, University of Bern, Bern, Switzerland.
Investigative radiology
|October 20, 2023
概括
下一代基于加多的对比剂 (GBCA) 和基于的对比剂显示出改善医学成像的前景. 研究强调了现有GBCA的潜在替代品和化合物的新应用,以及AI.
科学领域:
- 放射学和医学成像学 医学成像学
- 对比剂开发对比剂开发
- 纳米技术纳米技术
背景情况:
- 目前的基于加多的对比剂 (GBCA) 面临着下一代化合物的潜在替代.
- 经过数十年的有限研究,基于的药物正在重新出现,具有显著的临床潜力.
研究的目的:
- 审查下一代基于的对比剂 (GBCA) 和基于的对比剂.
- 讨论针对癌症和原体疾病检测的新型向GBCA的潜力.
- 探索新化合物的临床应用以及人工智能对对比剂开发的影响.
主要方法:
- 综述最近GBCA和基于的对比剂研究的进展.
- 对新的向性加多酸盐 (MT218,ProCA32.collagen) 的分析.
- 对临床用途的化合物 (化四水合物,Mn-PyC3A) 的评价.
主要成果:
- 加多皮克伦醇和加多夸特兰即将取代当前的宏循环GBCA.
- 两种新的向加多酸显示出改善癌症和原体疾病成像的希望.
- 两种基于的药物显示出用于肝脏成像和作为GBCA替代品的高潜力.
结论:
- 下一代GBCA和新型剂代表了医学成像技术的重大进步.
- 向剂为癌症和原相关疾病提供了更好的特异性.
- 人工智能有望优化GBCA剂量,并确定新的临床应用.
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