葡萄糖指数作为急性手术腹部儿童的炎症标记:一个横截面研究
Hoda Atef Abdelsattar Ibrahim1, Sherif Kaddah2, Sara Mohamed Elkhateeb3
1Paediatric Clinical Nutrition Unit, Paediatric Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
手术前高血糖和HbA1c水平表明,患有急性手术腹部的儿童有炎症. 随机血糖 (RBS) 可以预测严重程度,而HbA1c可以作为炎症标志物.
科学领域:
- 儿科手术 儿科手术
- 内分泌学 在内分泌学.
- 炎症研究 炎症研究
背景情况:
- 血糖失调会加剧炎症和氧化应激,将手术前高血糖症与死亡率增加联系起来.
- 炎症与高血糖血红蛋白 (HbA1c) 相对应,与随机血糖 (RBS) 有潜在的非线性关系.
研究的目的:
- 调查血糖参数 (HbA1c和RBS) 作为急性手术腹部的儿科患者潜在的炎症标志物的作用.
- 评估RBS,HbA1c和炎症标志物之间的相关性,如该患者组的全白细胞计数 (TLC).
主要方法:
- 一项涉及非糖尿病儿科患者的横截面研究,在六个月内患有急性手术腹部.
- 在注册患者中随机查血糖 (RBS) 和糖化血红蛋白 (HbA1c) 水平.
主要成果:
- 葡萄糖失调的高患病率 (66%的HbA1c异常,60%的压力高血糖症).
- 在RBS和全白细胞计数 (TLC) 之间存在显著的相关性 (r=0.770,p<0.001).
- 与无并发症病例相比,复杂尾炎的RBS升高.
结论:
- HbA1c和RBS可以作为急性手术腹部及其严重程度的炎症标志物.
- RBS可以作为替代性炎症标志物,随着疾病的进展而增加,由于压力高血糖症.
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