肠道大麻素受体亚型-1在焦虑的行为表达中的性二态作用
Courtney P Wood1, Bryant Avalos1, Camila Alvarez1
1Division of Biomedical Sciences, School of Medicine, University of California, Riverside, Riverside, California, USA.
Cannabis and cannabinoid research
|October 20, 2023
概括
在肠道中删除大麻素受体亚型-1 (CB1R) 减少了雄性小鼠但不是雌性小鼠的焦虑类行为. 这表明肠道内分泌大麻素系统根据性别不同地影响焦虑.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 内分泌学 在内分泌学.
背景情况:
- 大脑的内分泌大麻素系统 (ECS) 调节焦虑,CB1R信号影响行为.
- 肠道ECS在焦虑中的作用和性别差异在很大程度上是未被探索的.
- 大脑中的CB1R干扰增加了焦虑;激活是抗焦虑的.
研究的目的:
- 为了调查肠道CB1R是否控制焦虑类行为.
- 要确定这些影响是否取决于性别.
主要方法:
- 条件删除小鼠肠表皮中的CB1Rs (intCB1-/-).
- 行为测试:升高加迷宫,光/黑暗盒,开放场测试.
- 测量血皮质 (CORT) 水平.
主要成果:
- 与对照组相比,雄性intCB1-/-小鼠显示焦虑类行为减少.
- 在雌性intCB1-/-小鼠中没有观察到焦虑类行为的显著差异.
- 无论基因型如何,女性的基线和后压力CORT水平都高于男性.
结论:
- 肠道CB1R删除与雄性小鼠的抗焦虑作用有关.
- 肠道内分泌系统对焦虑的影响是取决于性别的.
- 肠道CB1Rs代表了焦虑障碍的潜在治疗标,并考虑了性别特异性.
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