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比率对改善基于患者的实时质量控制 (PBRTQC) 绩效的影响
Yuanyuan Li1,2,3, Xiaoling Chen1,2,3, Ying Zhao1,2,3
1Department of Laboratory Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, P.R. China.
Clinical chemistry and laboratory medicine
|October 20, 2023
概括
在基于患者的实时质量控制 (PBRTQC) 中使用分析剂比率显著改善了与单个分析剂相比的系统错误检测. 这种方法提高了PBRTQC对具有高生物变异性的分析物的性能.
科学领域:
- 临床化学 临床化学
- 实验室医学 实验室医学
- 质量控制 质量控制 质量控制
背景情况:
- 基于患者的实时质量控制 (PBRTQC) 对实验室的准确性至关重要.
- 对有效的PBRTQC而言,分析物的巨大生物变异构成了重大挑战.
- 现有的PBRTQC方法与表现出大量生物变异性的分析物扎.
研究的目的:
- 调查使用分析物比对PBRTQC性能的影响.
- 为了确定分析比率是否提高了PBRTQC的错误检测能力.
- 为了比较PBRTQC中分析物比率与单个分析物的疗效.
主要方法:
- 对单个分析物进行了四个分析物比率对 (例如,ALT/RALT,Cr/RCr) 的评估.
- 评估了传统的PBRTQC算法:移动平均 (MA),移动中位数 (MM),EWMA和移动标准偏差 (MSD).
- 引入并评估了一种新的算法,用于监测每次分析运行 (NDR) 缺陷报告的数量.
主要成果:
- 分析剂比率显著减少了用于系统错误 (SE) 检测所需的样本数量 (p<0.05).
- 比率增强了MA,MM和EWMA算法的SE检测.
- 比率对随机错误 (RE) 检测的影响是分析物和参数依赖的.
- 该NDR算法表现良好,但仅限于单边的SE;它是强大的样本重新排序,与传统方法不同.
结论:
- 采用分析剂比率作为PBRTQC指数,可以大大提高高变量分析剂的性能.
- 比率提供了增强的反干扰能力,为PBRTQC提供了一个新的监控策略.
- 这种方法为改善实验室质量控制提供了一种有价值的新类指标.
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