在EDNRB2位点的一个等位基序列控制着家用子中的多种形模式
Emily T Maclary1, Ryan Wauer1, Bridget Phillips1
1School of Biological Sciences, University of Utah, Salt Lake City, Utah, United States of America.
PLoS genetics
|October 20, 2023
概括
研究人员确定了一个关键基因,EDNRB2,负责家子的皮皮化. 这个基因,这个基因.
科学领域:
- 遗传学 是一个遗传学.
- 发展生物学 发展生物学
- 动物科学动物科学
背景情况:
- 颜料模式的变化影响脊椎动物的健康和生存.
- 由于选择性繁殖,家 (Columba livia) 呈现出广泛的羽毛多样性,使其成为一种有价值的模型生物体.
- 皮皮,以有色素和无色素的羽毛斑点为特征,是子的常见和遗传性特征.
研究的目的:
- 为了绘制家用子皮皮的遗传结构.
- 为了确定特定的基因和基因变异,这些基因变异是多种不同形羽毛图案的基础.
- 通过选择性繁殖了解色素模式多样化的进化机制.
主要方法:
- 在F2实验室交叉中绘制定量特征位置 (QTL) 映射.
- 在多种子品种中进行全基因组关联分析 (GWAS).
- 在已识别的位置内对候选基因的哈普洛型分析.
主要成果:
- 在众多的子品种中发现了与化相关的共同遗传位点.
- 候选基因EDNRB2,一种已知调节色素细胞发育的基因,被精确地定位在这个位置.
- 在EDNRB2中,多个不同的单质类型,包括编码,非编码和结构变异,被发现与特定的脱色模式相关.
结论:
- EDNRB2基因在养子中产生多样化的形色素模式方面发挥着重要作用.
- 对EDNRB2位点的重复选择导致了广泛的稳定,可遗传的羽毛变异的进化.
- 这项研究提供了关于脊椎动物色素和模式形成的遗传基础的见解.
相关概念视频
01:39Epistasis
46.9K
In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...
46.9K
01:09Epistasis Analysis
5.0K
Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...
5.0K
01:11Genetic Lingo
102.9K
Overview
102.9K
01:43Incomplete Dominance
22.6K
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
22.6K
02:32Position-effect Variegation
6.3K
In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
6.3K
02:41Lethal Alleles
15.5K
Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
15.5K