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在多功能PLA纤维中,抗微生物和阴离子聚甲酸盐的协同组合

Alberto Chiloeches^1,2, Jakub Zágora³, Daniela Plachá³

¹Instituto de Ciencia y Tecnología de Polímeros (ICTP-CSIC), C/Juan de la Cierva 3, Madrid 28006, Spain.

ACS applied bio materials

|October 20, 2023

概括

这项研究探讨了用于伤口包裹的阴性聚合物和临时性L抗菌的组合. 虽然结合显示出对抗性,但将它们纳入纤维通过强大的活性和非漂水聚合物增强了抗菌性能.

科学领域:

生物材料科学生物材料科学
抗菌研究抗菌研究
聚合物化学聚合物化学

背景情况:

抗菌素耐药性需要新的治疗策略.
结合抗微生物药物可以提高疗效和抗击耐药性.
生物基聚合物和抗微生物 (AMP) 具有生物医学应用的潜力.

研究的目的:

为了研究一个cationic生物基聚合物和temporin L. L. 的协同抗微生物作用.
开发用于伤口包装应用的多功能电纤维.
评估单个成分及其合物的抗菌活性.

主要方法:

合成一个可点击的,生物基聚合物功能化与 thiazolium 组 (PTTIQ).
使用点击化学创建一个聚合物-联体 (PTTIQ-AMP).
通过超临界溶剂浸将PTTIQ和temporin L纳入聚乳酸) 电纤维.

主要成果:

PTTIQ-AMP合物表现出对抗性抗菌作用,可能是由于聚合.
含有PTTIQ和temporin L的电纤维显示出增强的抗菌性能.
纤维效率的提高是由于temporin L的强大活性和PTTIQ的非漂水特性.

结论:

对于抗微生物药物协同作用来说,PTTIQ和temporin L的共价结合不是最佳的.
包括PTTIQ和temporin L在内的电纤维是有效的伤口带的有希望的策略.
开发的纤维具有增强的长期抗菌活性,适合生物医学应用.

关键词:

抗微生物药物是一种抗菌药物.抗微生物是一种抗微生物.化聚合物是一种化聚合物.纤维纤维是一种纤维.超临界浸方式

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