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LncRNA SNHG12:人类疾病的新星

Soudeh Ghafouri-Fard¹, Hamed Shoorei², Bashdar Mahmud Hussen³

¹Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Pathology, research and practice

|October 20, 2023

概括

小核RNA宿主基因12 (SNHG12),长非编码RNA,作为一个分子海绵影响众多信号通路和人类疾病. 它在癌症发病过程中的作用使SNHG12成为一个有前途的诊断和预后标志物.

科学领域:

分子生物学分子生物学
遗传学是一个遗传学.
生物化学生化学

背景情况:

小核RNA宿主基因12 (SNHG12) 是一种长非编码RNA (lncRNA),涉及各种人类病理.
SNHG12的功能就像一个分子海绵,与多个微RNA (miRNA) 相互作用.

研究的目的:

审查SNHG12在人类疾病中的多方面的作用,重点是癌症.
突出SNHG12在生物医学研究中的诊断和预后潜力.

主要方法:

对研究SNHG12功能的文献综述.
分析SNHG12与miRNA的相互作用及其对细胞信号通路的影响.
评估SNHG12在各种疾病,特别是癌症的发病过程中的作用.

主要成果:

在SNHG12的海绵中,有许多miRNA,包括miR-200c-5p,miR-129-5p和miR-16.
它调节关键的信号通路,如HIF-1α,Wnt/β-catenin,VEGF,PI3K/AKT/mTOR,NF-κB和ERK-1/2.2.等.
SNHG12参与了影响生殖尿道,胃肠道,肺部,中枢神经和心血管系统的疾病的发病.

结论:

SNHG12在人类疾病的发病过程中发挥着重要作用,尤其是癌症.
它作为miRNA海绵的功能及其对信号通路的影响强调了它作为诊断和预后生物标记物的潜力.

关键词:

生物标志物生物标志物癌症癌症癌症癌症表达方式表达方式表达这是一个LncRNARNA.在SNHG12中,SNHG12是SNHG12中的一个.

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