纵向核体抗体测试揭示了肺癌患者的未经记录的SARS-CoV-2感染
Ananda M Rodilla1, Rajesh M Valanparambil2, Philip C Mack1
1Center for Thoracic Oncology, Tisch Cancer Institute and Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Cancer cell
|October 20, 2023
概括
肺癌患者的SARS-CoV-2感染率高于报告的水平. 在接种疫苗的肺癌患者中监测抗核囊抗体显示,实际感染率几乎是感染率的两倍,这表明许多病例未被报告.
科学领域:
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 患有肺癌 (LC) 的患者对SARS-CoV-2的敏感性增加.
- 鉴于疫苗接种LC患者的脆弱性,评估SARS-CoV-2感染率至关重要.
研究的目的:
- 评估在完全接种疫苗的肺癌患者中实际的SARS-CoV-2感染率.
- 为了将实际的感染率与该队列的记录率进行比较.
- 了解肺癌患者中无症状或未报告的SARS-CoV-2感染的患病率.
主要方法:
- 在一组完全接种疫苗的肺癌患者中监测血抗核囊抗体水平.
- 将抗体指示感染率与官方报告的COVID-19病例进行比较.
- 分析数据以确定实际和记录的感染率之间的差异.
主要成果:
- 该研究发现,在完全接种疫苗的肺癌患者中,实际的SARS-CoV-2感染率几乎是记录率的两倍.
- 这表明大量感染未报告或无症状.
- 血抗核囊抗体水平作为过去感染的可靠指标.
结论:
- 肺癌患者,即使接种了疫苗,也可能会经历比官方记录的更高的SARS-CoV-2感染负担.
- 在肺癌患者群体中,存在大量未报告的SARS-CoV-2感染的流行率.
- 这些发现凸显了加强监测和针对癌症患者等免疫受损人群的潜在定制预防策略的需要.
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