合理设计的酸盐互穿式冷珠,功能化用聚烯胺链:通过赫兹模型和弹性进行比较分析
Birgul Kalkan1, Rabia Bozbay2, Sena Ciftbudak2
1Istanbul Technical University, Department of Chemistry, Soft Materials Research Laboratory, 34469 Maslak, Istanbul, Turkey; Present Address: Max Planck Institute of Colloids and Interfaces, Potsdam, Brandenburg, Germany.
International journal of biological macromolecules
|October 20, 2023
概括
这项研究优化了基托 (CS) 基聚合物珠,提高了弹性和机械强度. 结晶聚合和CS结合显著改善了珠子的特性,使其成为可调节的药物释放载体的潜在应用.
科学领域:
- 材料科学 材料科学 材料科学
- 聚合物化学 聚合物化学
- 生物材料工程 生物材料工程
背景情况:
- 聚合物微球和凝珠为各种应用提供了设计优势.
- 了解交联色素 (CS) 珠的弹性对于优化其性能至关重要.
- 基于PNIPA/PAAm的半透聚合物网络 (半IPN) 提供可调节的特性.
研究的目的:
- 系统地研究交联色素 (CS) 珠的弹性分子基础.
- 为了优化合成含有CS的多 ((N-异烯胺-烯酸盐) /多烯胺 (PNIPA/PAAm-CS) 珠子.
- 评估聚合温度和凝制备对物理机械性能的影响.
主要方法:
- 半IPN PNIPA/PAAm-CS珠子的合成,使用冷聚合.
- 使用ATR-FTIR,热重力测量分析 (TGA) 和粉末X射线衍射 (PXRD) 的表征.
- 通过压缩试验和赫茨模型分析进行机械性能评估.
- 评估胀行为,pH反应和离子强度灵敏度.
主要成果:
- CS的合并和冷聚合显著提高了热稳定性和机械承载能力.
- 观察到压力弹性模量增加2倍,加上CS.
- 冷条件降低了聚合温度,改善了机械性能.
- 赫兹模型分析给出了1.63±0.19的缩放参数.
- 加大的冷珠直径导致更高的胀,而增加的胀降低了模量.
- 在酸性条件下,CS改善了pH反应;CS刚性减少了收缩.
- 氨盐和三聚酸增强了弹性模量.
- 通过调节盐度来实现冷珠的可逆开关.
结论:
- 成功优化了PNIPA/PAAm-CS半IPN冷珠的合成,从而产生了增强的机械和热性能.
- 结晶聚合和CS结合是调整珠子弹性和胀的有效策略.
- 准备好的冷珠显示出作为可调节的药物释放载体的潜力,以离子强度调节.
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