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由Bacillus licheniformis产生的细胞外纳米纤维:一种潜在的抗癌剂,用于乳腺和肺癌

Sangiliyandi Gurunathan¹, Abhishek Ajmani², Jin-Hoi Kim³

¹Department of Biotechnology, Rathinam College of Arts and Science, RathinamTechzone Campus, Eachanari, Coimbatore, 641 021, Tamil Nadu, India.

Microbial pathogenesis

|October 20, 2023

概括

细菌菌外细胞纳米微粒 (BENVs) 显示出作为一种更安全的癌症治疗的前景. 这些细菌囊泡抑制乳腺和肺癌细胞的生长,并诱导细胞亡,提供了一种新的治疗策略.

科学领域:

生物技术是生物技术.
癌症研究癌症研究
微生物学微生物学

背景情况:

癌症仍然是全球主要的死亡原因,需要新的治疗策略.
细菌衍生的产品正在探索用于癌症治疗,但整个细菌构成感染风险.
细菌细胞外囊泡 (BEVs) 是癌症治疗的非复制性,更安全的替代方案.

研究的目的:

为了研究Bacillus licheniformis细胞外纳米纤维 (BENVs) 的抗癌潜力.
评估BENV对人类乳腺癌 (MDA-MB-231) 和肺癌 (A549) 细胞的疗效.

主要方法:

从Bacillus licheniformis培养上游生物中净化和表征BENVs.
在体外治疗具有不同BENV度的癌症细胞系.
对细胞活力,增殖,细胞毒性,氧化应激标志物 (ROS,GSH) 和与亡相关的蛋白质 (p53,p21,caspases,Bcl-2家族) 的分析.

主要成果:

在剂量取决的方式上,BENVs显著抑制了乳腺和肺癌细胞的活力和增殖.
BENV治疗增加了活性氧物种 (ROS) 和降低了谷氨 (GSH) 水平,表明氧化应激.
通过对p53,p21,caspase-9/3,Bax进行上调和对Bcl-2进行下调,BENVs诱导了亡,与多克索鲁比辛结合时效果得到增强.

结论:

来自Bacillus licheniformis的BENVs对乳腺癌和肺癌细胞具有显著的抗癌特性.
BENVs通过诱导氧化应激和亡来发挥其治疗作用.
这项研究强调了BENVs作为癌症治疗的有前途,新和安全的治疗剂.

关键词:

这是一种抗癌药物.细胞灭亡 (apoptosis) 是一种死亡的过程.细菌类类类细菌的细胞外囊泡.氧化应激是一种氧化应激.

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