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对神经和G蛋白结合受体 (GPCRs) 在Sunn害虫,Eurygaster integriceps Puton中的转录组范围的识别

Mehrbano Kazemi Alamouti¹, Mohammad Majdi², Reza Talebi³

¹Department of Plant Genetics and Production, Faculty of Agriculture, University of Kurdistan, P. O. Box: 416, Sanandaj, Iran; Department of Systems and Synthetic Biology, Agricultural Biotechnology Research Institute of Iran, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran.

|October 20, 2023

概括

研究人员在主要的小麦害虫Sunn害虫中确定了46种神经和85种G蛋白结合受体 (GPCR). 这一发现有助于了解害虫行为,并制定新的害虫管理策略.

科学领域:

昆虫分子生物学昆虫分子生物学
文字转录学 (Transcriptomics) 是一个学科.
害虫管理害虫管理害虫管理

背景情况:

苏恩虫害 (Eurygaster integriceps) 对小麦作物造成了重大经济损害.
神经和G蛋白结合受体 (GPCRs) 对于调节昆虫生理和行为至关重要.

研究的目的:

识别Sunn害虫中编码神经和假定的GPCR的基因.
为了深入了解Eurygaster中神经调节的过程.

主要方法:

使用来自成年Sunn害虫的配对末端RNA测序数据进行de novo转录组组.
神经和GPCR基因的识别和表征.

主要成果:

识别了46种神经,包括四种新型神经类.
发现了85个假定的神经基基基因复原酶,包括昆虫中罕见的C类GPCR.
识别的GPCR与棕色大理石臭虫具有很高的同源性 (80%),但与其他昆虫物种只有20%.

结论:

鉴定到的神经和GPCRs为了解Sunn害虫神经生物学提供了基础.
这项研究可能会导致针对Eurygaster integriceps的针对性,基于神经的害虫防治策略的开发.

关键词:

昆虫昆虫是一种昆虫.神经是一种神经.在RNA-seqqq.太阳的害虫是太阳的害虫

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相关概念视频

Transducer Mechanism: G Protein–Coupled Receptors

Transducer Mechanism: G Protein–Coupled Receptors

G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
GPCRs are also called heptahelical, 7TM, or...