老年COVID-19血液病患者的年龄,连续波,免疫和死亡率:EPICOVIDEHA的发现
Giuseppe Rossi1, Jon Salmanton-García2, Chiara Cattaneo1
1Hematology Unit, ASST-Spedali Civili, Brescia, Italy.
概括
患有血液癌症的老年患者因年龄和流行病浪潮而面临不同的COVID-19影响. 疫苗接种和及时治疗显著改善了这个脆弱群体的生存率.
科学领域:
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
- 老年病的医生 老年病的医生
- 流行病学 流行病学
背景情况:
- 患有血液性恶性瘤的老年人面临严重COVID-19的高风险.
- 缺乏对该人口中不同年龄组的COVID-19影响的详细分析.
研究的目的:
- 为了研究COVID-19对患有血液性恶性瘤的老年患者的影响.
- 为了确定影响不同年龄层和流行病波的这一队列死亡率的因素.
主要方法:
- 从EPICOVIDEHA注册表 (2020年1月至2022年7月) 分析了3,603名患有血液性恶性病的老年患者 (≥65岁).
- 分为四个年龄组 (65-70,71-75,76-80,>80岁) 的分层.
- 单变量和多变量考克斯回归模型用于确定死亡率预测因素.
主要成果:
- 总体90天生存率为71.2%,在各年龄组和流行病浪潮中存在显著差异.
- 第一波影响最严重的是80岁以上的人群,第二波影响65-70岁的人群,第三波影响最不严重.
- 死亡率预测因素包括晚年,并发病,淋巴缺血,活跃恶性瘤,急性白血病,三次疫苗剂量,严重的COVID-19和皮质类固醇单疗法.
结论:
- 患有血液性恶性瘤的老年患者对COVID-19呈现异质反应.
- COVID-19 波及疫苗接种情况显著影响了结果.
- 这些发现有助于对风险进行分层,并为这一群体规划针对性的医疗干预措施.
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