大麻二醇 (CBD) 产品治疗疼痛:无效,昂贵,并具有潜在的危害
Andrew Moore1, Sebastian Straube2, Emma Fisher3
1Newton Ferrers, Plymouth, UK.
The journal of pain
|October 20, 2023
概括
大麻素 (CBD) 产品通常缺乏广告中的CBD含量,并且可能含有有害化学物质. 临床试验表明,CBD在缓解疼痛方面基本上无效,可能会带来安全风险.
科学领域:
- 药理学和毒理学 药理学和毒理学
- 疼痛管理 疼痛管理
- 监管科学 监管科学
背景情况:
- 大麻 (CBD) 被广泛推销为健康益处,特别是缓解疼痛,但通常违反广告法规.
- 有关商业产品中CBD含量和纯度的准确性存在担忧,这些产品可能含有有害污染物.
- 以前的评估没有发现关于CBD治疗疼痛的试验,突出了证据上的差距.
研究的目的:
- 根据最近的临床试验,评估大麻素 (CBD) 治疗疼痛的疗效和安全性.
- 评估CBD含量的变化和商用CBD产品中杂质的存在.
- 为消费者和医疗保健提供者提供有关CBD在疼痛治疗中的使用现有证据的信息.
主要方法:
- 对16项随机对照试验 (RCT) 进行系统审查,调查CBD用于各种疼痛条件.
- 分析北美和欧洲可用的CBD产品的产品质量,包括CBD含量和化学纯度.
- 检查报告的不良事件和来自临床试验和市场后监测的安全数据.
主要成果:
- 在16个RCT中,有15个没有发现CBD在治疗疼痛方面与安慰剂相比没有显著的益处.
- 商业CBD产品经常表现出不准确的CBD度,并且可能含有未申报的潜在有害物质.
- 虽然一些小型试验表明CBD是良性的,但越来越多的证据将其与严重的不良事件联系起来,包括肝毒性.
结论:
- 目前的证据表明,CBD是一种昂贵且无效的疼痛治疗方法.
- 对于CBD产品的质量,纯度和安全性仍然存在重大担忧,需要监管监督.
- 消费者应该寻求基于证据的信息,而不是依靠产品广告来确定CBD在疼痛管理中的有效性和安全性.
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