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含有卷状卷状域的154通过与小染色体维护复合元件2的相互作用促进结直肠癌的扩散和转移
Wei-Feng Hong1, De-Xiang Zhu2, Yan-Jie Chen3
1Department of Radiation Oncology, Zhongshan Hospital, Fudan University, NO. 180, Fenglin Road, Xuhui District, Shanghai, 200032, People's Republic of China.
Cancer letters
|October 20, 2023
概括
卷卷域含蛋白 (CCDC) 在结直肠癌 (CRC) 中起作用. 过度表达CCDC154预测存活率较低,并影响CRC患者的免疫细胞透.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 免疫学 免疫学 免疫学
背景情况:
- 卷曲卷曲域含有 (CCDC) 蛋白质是结构性蛋白质,在结直肠癌 (CRC) 中的作用尚不清楚.
- 了解CCDC蛋白的功能对于识别CRC的新治疗点和预后标志物至关重要.
研究的目的:
- 研究CCDC蛋白在结直肠癌 (CRC) 中的临床意义和功能作用.
- 为CRC患者开发基于CCDC蛋白表达的预后模型.
主要方法:
- 利用癌症基因组图谱 (TCGA) 数据对CRC中CCDC蛋白的遗传,转录和临床分析.
- 生物信息分析,以探索卷曲卷曲域含154 (CCDC154) 的功能及其与小染色体维护复合元件2 (MCM2) 的相互作用.
- 在临床CRC样本中验证了CCDC154表达和预后价值,分析了与MCM2,Ki-67和p53的共同表达.
主要成果:
- 在36种CCDC蛋白中,有5种在CRC中差异表达,与患者存活率相关.
- 为患者预后开发了一个CCDC-score模型.
- 高CCDC154表达与CRC存活率低下,CD8+T细胞透率降低和中性粒细胞透率增加有关.
- CCDC154与MCM2相互作用,促进CRC恶性病变和转移.
结论:
- CCDC蛋白对结直肠癌具有重要的临床影响.
- CCDC154作为CRC中的潜在瘤基因,通过与MCM2相互作用和影响瘤免疫微环境,促进瘤生长和转移.
- 在CRC患者中,CCDC154作为一个有价值的预后生物标志物.
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