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使用单克隆抗体进行微分类和冷化之间的稳定性比较

Karthik Balakrishna Chandrababu1, Aadithya Kannan2, John R Savage1

  • 1Lindy Biosciences, 627 Davis Dr. #400 Morrisville, North Carolina 27560, United States.

Journal of pharmaceutical sciences
|October 20, 2023
PubMed
概括

微分类TM提供了一种创新的方法,可以通过避免脱水过程中的热应激来创建稳定的固态生物制剂,如单克隆抗体. 这种新技术证明了与传统冷化相比,蛋白质的稳定性相当.

关键词:
抗体是药物中的一种抗体.化学稳定性 化学稳定性脱水,冷化 脱水,冷化微粒子 (微粒子) 是指微小的粒子.单克隆抗体 (monoclonal antibody) 是一种单克隆的抗体.蛋白质配方是一种蛋白质配方.蛋白质 (s) 蛋白质 (s) 蛋白质 (s)固态稳定性的稳定性

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