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基因多态性和药物相互作用决定了布隆纳塞林的代谢概况

Feng Ye1, Xinyue Li1, Jinhuan Ni1

  • 1Institute of Molecular Toxicology and Pharmacology, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.

The Journal of pharmacology and experimental therapeutics
|October 20, 2023
PubMed
概括

细胞染色体P450 3A4 (CYP3A4) 基因变异显著改变了布洛南塞林代谢,其中一些减少了清除,另一个增加了清除. 尼莫迪平,费洛迪平和阿姆洛迪平抑制了布洛南塞林的新陈代谢,影响了其临床使用.

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