干细胞移植后患者的胃肠道活检:一种诊断方法
Tao Zhang1, Catherine E Hagen1
1Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 1st Street Southwest, Rochester, MN 55905, USA.
Surgical pathology clinics
|October 20, 2023
概括
移植与宿主疾病 (GVHD) 是干细胞移植后的一种严重并发症. 区分胃肠道GVHD与其他疾病,如药物损伤或感染,对于患者管理至关重要.
科学领域:
- 医学 医学 医学 医学 医学
- 病理学 病理学 病理学
- 在瘤学瘤学.
背景情况:
- 移植与宿主疾病 (GVHD) 是血液造血干细胞移植 (SCT) 后的一种严重并发症.
- 胃肠道GVHD在组织学上呈现出密码亡和脱学.
- 在药物诱导的损伤和机会性感染中可以观察到类似的组织学特征.
研究的目的:
- 审查从SCT患者的胃肠道活检中亡的病理差异诊断.
- 要突出关键的诊断考虑区分胃肠道GVHD.
主要方法:
- 文献综述侧重于组织学特征和诊断标准.
- 分析了在SCT患者中帮助差异诊断的因素.
主要成果:
- GVHD,药物损伤和感染之间的组织学相似性需要仔细评估.
- 临床背景,包括活检时间,药物,感染状况和其他器官参与至关重要.
结论:
- 胃肠道GVHD的准确诊断依赖于将组织学发现与临床信息相结合.
- 区分GVHD与其他导致胃肠道病理的原因对于SCT后适当的患者管理至关重要.
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