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沙尔科病的循环T细胞具有异常激活的表型,与疾病结果相关

Jelle R Miedema¹, Lieke J de Jong¹, Denise van Uden¹

¹Department of Pulmonary Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.

Journal of autoimmunity

|October 20, 2023

概括

皮质硬化症患者的外周血液T细胞差异,包括CD4+T细胞减少和调节性T细胞 (Tregs) 增加,与更糟糕的疾病结果相关. 这些发现凸显了在沙尔科毒症病原体中的异常T细胞激活.

科学领域:

免疫学免疫学免疫学
细胞生物学细胞生物学
肺部医学肺部医学

背景情况:

Sarcoidosis 具有可变的疾病过程,T-辅助 (Th) 17.1 细胞在受影响的组织中积累.
这种积累与不溶解的沙尔科毒性相关,这表明T细胞在疾病持续性中的作用.

研究的目的:

为了比较循环T细胞频率,表型和功能,在肉病患者与健康对照 (HCs).
为了将这些外周血液T细胞参数与沙尔科病症疾病结果相关联.

主要方法:

多色流细胞测量被用来分析外围血液T细胞子集在未经治疗的肉类瘤患者和HCs.
疾病的发展过程在2年的随访期间进行了评估.
进行了体外T细胞刺激以测量细胞因子的产生.

主要成果:

在T细胞种群中观察到显著的差异,包括CD4+,CD8+,Th1/Th17,T记忆干细胞,调节性T细胞 (Tregs) 和γδT细胞.
减少CD4+ T细胞和增加Tregs和CD8+ γδ T细胞与更糟糕的结果相关.
在慢性疾病中,原始的CD4+T细胞表现出激活 (CD25表达),一个独特的Treg表型 (CD25,CTLA4,CD69,PD-1,CD95表达) 与慢性沙尔科毒症有关.

结论:

沙尔科发症患者的外围T细胞亚群表现出表型异常.
这些异常与疾病结局有关,支持异常T细胞激活在沙尔科毒症发病过程中的作用.

关键词:

激活标记器的激活标记器原始的T细胞.预测预后预测预测监管性T细胞监管性T细胞 Sarcoidosis 是一种癌症.

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