在COVID感染中骨肌损伤:频率和模式
Saurabh Singh Rajput1, Rajeswari Aghoram1, Vaibhav Wadwekar1
1Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.
Muscle & nerve
|October 20, 2023
概括
骨肌损伤在轻度至中度的COVID-19病例中很常见. 这项研究发现,22.4%的患者经历了肌肉损伤,经常影响部曲器,影响恢复.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 肌肉骨系统疾病 肌肉骨系统疾病
背景情况:
- 冠状病毒疾病2019 (COVID-19) 可以影响多个器官系统.
- 尚不清楚COVID-19对骨肌肉健康的影响.
- 调查COVID-19患者的肌肉损伤对于了解疾病后果至关重要.
研究的目的:
- 确定急性COVID-19患者骨肌损伤的频率.
- 探索与COVID-19相关的肌肉损伤的模式和特征.
- 检查骨肌损伤与疾病严重程度和结果之间的关系.
主要方法:
- 评估了250名患有轻度至中度COVID-19的患者队列.
- 骨肌损伤使用肌酸酶 (CK) 水平,手动肌肉测试-8 (MMT-8) 和健康评估问卷 (HAQ) 分数进行评估.
- 受伤的定义是CK升高 (>200 IU/L) 和MMT-8得分低 (<76).
主要成果:
- 在22.4%的参与者中观察到骨肌损伤.
- 虚弱 (MMT-8 < 76) 和残疾 (HAQ) 是常见的,分别影响了98.8%和42.8%的患者.
- 曲部肌肉经常受到影响;肌肉损伤和最大疾病严重程度或短期结果之间没有发现显著的关联.
结论:
- 骨肌损伤是患有轻度至中度COVID-19感染的个体的常见发现.
- 虽然与最初的严重程度没有直接关系,但是肌肉损伤可能会影响长期的康复和残疾.
- 需要进一步研究以了解COVID-19相关肌肉损伤的机制和长期影响.
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