在存在自然敌人的情况下,突变者固定
Dominik Wodarz1,2,3, Natalia L Komarova4,5
1Department of Population Health and Disease Prevention, University of California, Irvine, CA, 92697, US. dwodarz@ucsd.edu.
Nature communications
|October 20, 2023
概括
病原体的存在削弱了自然选择,改变了宿主群体中的突变固定动态. 这种生态相互作用增加了不利突变物传播和有利突变物消失的可能性.
科学领域:
- 生态生态学 生态生态学
- 进化生物学 进化生物学
- 人口遗传学 人口遗传学
背景情况:
- 传统的突变固定理论往往忽视了生态相互作用.
- 敌人-受害者动态,如病原体-宿主相互作用,在自然种群中很普遍.
研究的目的:
- 调查病原体存在如何影响突变入侵和固定在空间显式宿主群体.
- 在生态条件下重新评估已建立的突变固定理论.
主要方法:
- 利用空间显式的,计算型的病原体-宿主模型.
- 模拟野生类型和突变宿主与通用病原体之间的相互作用.
- 评估突变体适应性,独立于感染状态.
主要成果:
- 病原体的存在显著削弱了突变者的选择.
- 不利突变的固定概率增加,而有利突变的固定概率减少.
- 病原体对选择强度的影响与感染率相关.
结论:
- 生态相互作用,特别是病原体-宿主动态,可以大大改变进化轨迹.
- 感染诱导的空间结构导致通过创建竞争类型的"补丁"来削弱选择.
- 自然种群中有害突变的负担可能被非生态模型低估.
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