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Updated: Jul 12, 2025

Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro
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转录因子Zeb1控制1型常规树突细胞的恒常性和功能

Yan Wang1, Quan Zhang2,3, Tingting He1

  • 1State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian, 361102, China.

Nature communications
|October 20, 2023
PubMed
概括

树突细胞中的Zeb1缺乏减少了1型常规树突细胞 (cDC1),损害了它们的抗原交叉呈现. 这一途径涉及微RNA-96/182和NADPH氧化酶,影响T细胞的反应.

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