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Updated: Jul 12, 2025

Identification of Kinase-substrate Pairs Using High Throughput Screening
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灵长类动物特定的Nedd4-1异型通过Ser/Thr酸化和14-3-3结合来调节基质结合

George Kefalas1,2, Daniela Rotin3,4

  • 1Cell Biology Program, the Hospital for Sick Children, PGCRL 19-9715, 686 Bay Street, Toronto, ON, M5G 0A4, Canada.

Scientific reports
|October 20, 2023
PubMed
概括

替代拼接产生一种新的Nedd4-1(NE) 异型,具有增强的E3泛基因酶活性. 这种灵长类动物特有的变体表现出独特的基质相互作用和调节机制,扩大了Nedd4-1.的功能表现.

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