在404,302个个体的全基因组关联研究中,为反应时间变异性确定了7个显著的位置
Olivia Wootton1, Alexey A Shadrin2, Christine Mohn2
1Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa. wttoli001@myuct.ac.za.
Molecular psychiatry
|October 20, 2023
概括
反应时间变化 (RTV) 具有显著的遗传基础,已确定161个SNP. 这项研究支持RTV作为神经精神疾病的内类型,揭示了其与平均反应时间不同的遗传基础.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 精神病学是一个精神病学.
背景情况:
- 反应时间变化 (RTV) 是神经精神疾病的潜在内因型,但其遗传基础尚不清楚.
- 对RTV缺乏大规模的全基因组关联研究 (GWAS).
结论:
- 这项研究确定了RTV的新型遗传基础.
- 结果支持RTV作为神经和精神疾病的内类型的实用性.
- 对RTV的多基因评分显示了预测能力,但在祖先之间有限的概括性.
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