在中国SARS-CoV-2大流行之前和期间,PICU中的病原体:多中心回顾性研究
Jingwen Ni1,2, Zhe Zhao2, Chun Wang3
1Pediatric Intensive Care Unit, Luoyang Maternal and Child Health Hospital, Luoyang, China.
COVID-19控制措施减少了儿科重症监护室 (PICU) 的住院和细菌感染. 流感血球菌的发病率显著下降,而肺炎链球菌的发病率呈上升趋势.
科学领域:
- 儿科重症监护室的儿童重症监护室
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 在COVID-19大流行期间的非药物干预措施可能会影响儿科重症监护室 (PICU) 的入院率和细菌感染率.
- 在大流行之前和期间评估PICU患者细菌特征的变化对于理解这些影响至关重要.
研究的目的:
- 评估被录取到PICU的儿童中细菌特征的变化.
- 为了比较2019年与2021年PICU患者的细菌感染发病率.
主要方法:
- 对具有阳性细菌培养的儿童的临床数据进行了回顾性分析.
- 2019年和2021年PICU入院数据的比较.
主要成果:
- 与2019年相比,2021年的住院总数和PICU中的细菌感染在2019年相比较低.
- 在格拉姆阳性,格拉姆阴性或真菌感染的比率上没有发现显著差异.
- 血球菌流感的发病率显著下降 (p=0.002),而肺炎链球菌的发病率显示非显著增加 (p=0.127).
结论:
- COVID-19隔离和控制措施导致PICU住院和细菌感染减少,可能是由于人口行为的改变.
- 在住院儿科患者中观察到Haemophilus influenzae发病率的显著下降趋势.
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